Proteomics CRO · Framingham, MA
Quantitative proteomics for drug discovery
TMT, DIA and targeted LC-MS, chemoproteomics and PTM profiling, run end to end in our own lab by the Gygi Lab-trained scientists who founded it.
Since 2015
thousands of projects delivered
6
Orbitrap mass spectrometers
48
samples per day on the Orbitrap Astral
Trusted by nearly all of the world’s largest pharmaceutical companies, and the newest biotechs. Featured by Thermo Fisher Scientific: read the case study
Services
Start with your question
What changed in my system?
Discovery proteomics by TMT or DIA, more than 13,000 protein groups.
Learn moreWhich pathways are firing?
PTM proteomics: phosphorylation, ubiquitination, acetylation and others, site by site.
Learn moreEight services, from discovery to targeted assays. View all services
Chemoproteomics
Find the target. Rule out the false hits.
In a public study of sotorasib in H358 cells, our global cysteine profiling showed the KRAS G12C peptide disappearing with dose while KRAS protein held steady: engagement, not degradation. A companion proteome from the same samples exposed an apparent off-target hit as a change in protein level. Targeted assays then resolved engagement above 99%.
Explore chemoproteomics
Why IQ Proteomics
Rigor, in one lab, for drug discovery
Gygi Lab rigor
Our founders trained together in the Harvard Medical School lab where foundational TMT methods were developed, and they still run the science.
Meet our leadershipOne lab, end to end
Sample preparation, cell culture and LC-MS on six Orbitrap instruments, all in our Framingham laboratory. No subcontracting, no hand-offs.
See our facilitiesBuilt for drug discovery
From target identification to IND-enabling engagement assays, with methods that carry across every stage of a program.
Explore servicesThree routes, one platform
The right measurement for each stage
Programs often move from DIA screening, to precise TMT validation, to targeted PRM as candidates mature. Because all three share the same sample preparation and informatics, a project can switch route without restarting.
48/day
by DIA on the Orbitrap Astral
0
missing values within a TMT plex
>99%
target engagement resolved by PRM
Evidence
Proof in published work
Research built on our data
Thirty peer-reviewed papers draw on data from our laboratory. Browse publications
Our workflows, on real samples
Example datasets for each of our core workflows. Browse technical notes
Explore everything on our Reference page. Visit the Reference page
News
Latest news
All newsReady to discuss your project?
Tell us about your samples, timeline and scientific goals, and one of our founders will be part of the conversation.