Covalent small molecule inhibitors offer unique advantages over traditional drugs, including increased potency and prolonged efficacy. Notable irreversible inhibitors include Afatinib (EGFR), Ibrutinib (BtK), Neratinib (ErbB), and Sotorasib (RASK G12C). IQ Proteomics provides an LC-MS based, unbiased assay for screening the targets of cysteine-directed covalent inhibitors.
Features
• >15,000 Quantified Cys-Peptides
• High efficiency streptavidin-based enrichment
• TMTTM 18-Plex Technology & Orbitrap Eclipse (RTS-MS3)
Applications
• Target Identification
• Selectivity Profiling
• High Throughput Screening
Associated reference: https://www.nature.com/articles/s41586-019-1694-1