Phenotypic screening for small molecules that lower PrP in cultured cells
Discovery proteomics
IQP co-authoredPublications, technical notes and news
Peer-reviewed papers, application notes and company news from IQ Proteomics and the teams we work with.
Publications
Research built on our data
Thirty peer-reviewed papers from customers and collaborators draw on data from our laboratory. Filter by service to find work like yours.
Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model
Chemoproteomics
Quantitative transcriptome and proteome maps of classical nonclinical species
Discovery proteomics
PrP turnover in vivo and the time to effect of prion disease therapeutics
Targeted proteomics
IQP co-authoredPharmacological PIK3C2B inhibition rescues XLMTM phenotype in mouse models and identifies molecular markers of disease
Discovery proteomics
Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway
Discovery proteomics
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
Chemoproteomics
Anellovirus protein encoded by ORF2/3 functions as the viral replication initiation protein
Protein interactions
The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming
Discovery proteomics
Discovery of BMS-986365, a First-in-Class Dual Androgen Receptor Ligand-Directed Degrader and Antagonist, for the Treatment of Advanced Prostate Cancer
Targeted protein degradation
Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
Chemoproteomics
The IL-4–IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell
Discovery proteomics
Eribulin Induction of Immunogenic Cell Death (ICD): Comparison With Other Cytotoxic Agents and Temporal Relationship of ICD Biomarkers
Discovery proteomics
IQP co-authoredEvidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker
Plasma & biofluid
IQP co-authoredConcurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Discovery proteomics
Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans
Plasma & biofluid
Targeted proteomics
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface
Protein interactions
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration
Discovery proteomics
Nanoscale Mapping of EGFR and c-MET Protein Environments on Lung Cancer Cell Surfaces via Therapeutic Antibody Photocatalyst Conjugates
Protein interactions
Discovery of surface biomarkers for cell mechanophenotype via an intracellular protein-based enrichment strategy
Discovery proteomics
Comparative proteomics analysis of Arabidopsis thaliana response to light-emitting diode of narrow wavelength 450 nm, 595 nm, and 650 nm
Discovery proteomics
Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention
Discovery proteomics
Enrichment of Tyrosine Phosphorylated Peptides for Quantitative Mass Spectrometry Analysis of RTK Signaling Dynamics
PTM proteomics
IQP co-authoredA CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
Discovery proteomics
Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response
Discovery proteomics
IQP co-authoredCC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia
Targeted protein degradation
Microenvironment mapping via Dexter energy transfer on immune cells
Protein interactions
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes
Discovery proteomics
Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation
Discovery proteomics
Targeted proteomics
IQP co-authoredTechnical notes
Our workflows, on real samples
Short application notes showing what each service delivers, with example data.
Chemoproteomics
Covalent inhibitor profiling
Read the noteTargeted proteomics
Custom targeted proteomics assays
Read the noteTargeted protein degradation
Dose-resolved degrader profiling: dBET1 in Jurkat cells
Read the noteDiscovery proteomics
Label-free DIA proteome profiling
Read the noteOverview of IQP services
Read the notePTM proteomics
Phosphoproteome profiling
Read the noteDiscovery proteomics
Proteome profiling
Read the noteProtein interactions
Quantitative-IP
Read the notePTM proteomics
Ubiquitylome profiling
Read the noteNews
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