Quantitative PTM Analysis
Amenable samples
- Primary tissues
- Cell culture
Typical Metrics (cell culture / tissues, pST)
- 15,000 quantified sites
- 50,000 quantified peptides
- 500,000 quantitative measurements
Post-translational modifications (PTM) are key regulators of cell state. Through our multiplexed PTM analysis we provide comprehensive characterization of the modified proteome. Potential applications include drug / dosage response, longitudinal studies, and high replicate analyses for high statistical power.
Survey of phosphoproteome following DNA damage
A cluster of protein sites (right side of heat map) exhibit a marked increase in phosphorylation occupancy.
Quantifying p53 phosphorylation
The phosphorylation site (serine 315) of p53 exhibited a near infinite change in occupancy following DNA damage.
