Post-translational modifications (PTM) are key regulators of cell state. Through our
multiplexed PTM analysis we provide comprehensive characterization of the modified proteome. Potential applications
include drug / dosage response, longitudinal studies, and high replicate analyses for high statistical power.
Survey of phosphoproteome following DNA damage
A cluster of protein sites (right side of heat map) exhibit a marked increase
in phosphorylation occupancy.
Quantifying p53 phosphorylation
The phosphorylation site (serine 315) of p53 exhibited a near
infinite change in occupancy following DNA damage.